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Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2004 Jun; 135(6):619-28. 2000 Sep 29; 275(39):30597-604. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2009 Apr; 136(4):1423-34. Exp Biol Med (Maywood). Int J Mol Med. J Clin Invest. N Engl J Med. 2004 Aug 15; 78(3):324-32. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Am J Physiol Gastrointest Liver Physiol. Stroke. The gut-liver axis and the intersection with the microbiome. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Nat Commun. 2005; 23(3-4):255-63. Cell Metab. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2018 12; 16(12):1974-1982.e7. Hepatology. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. 2011 Apr; 25(2):305-17. J Clin Invest. 2001 Dec; 281(6):G1357-68. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Am J Physiol. Am J Physiol Gastrointest Liver Physiol. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Integr Biol (Camb). Gastroenterology. Mol Cell Biol. Hepatology. Derived automatically from this person's publications. 2010 Jul; 139(1):323-34.e7. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 2018 06; 67(6):2150-2166. 2015 Jul; 22(7):512-8. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Mol Cell Biol. Brain Commun. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Fibrogenesis Tissue Repair. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Mitogens and hepatocyte growth control in vivo and in vitro. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Mechanisms of fibrogenesis. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. 2006 Jul; 37(7):1691-6. 1979 Sep-Oct; 52(5):449-54. DNA Cell Biol. J Gastroenterol Hepatol. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Proc Natl Acad Sci U S A. Hepatology. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 1997 10; 273(4):G795-803. 2010 Jul; 26(4):395-402. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. CCR1 and CCR5 promote hepatic fibrosis in mice. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Cell Metab. Cancer Res. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. 2008 Mar; 23 Suppl 1:S98-103. 1989 Oct 05; 264(28):16957-62. Contemp Intern Med. Biotechniques. 2000; 35 Suppl 12:80-3. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Nat Rev Gastroenterol Hepatol. 2003 Apr; 37(4):833-41. 2016; 34(5):589-96. Gastroenterology. Mol Cell Biol. 2010 Jan 12; 107(2):844-9. 2021 03; 18(3):151-166. Mol Pharmacol. 1989 Jun 05; 264(16):9583-91. Am J Physiol. 2000 Apr 21; 275(16):12207-13. 2007 Jun; 22 Suppl 1:S73-8. 2003 Mar 07; 278(10):8083-90. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Ital J Gastroenterol Hepatol. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. J Lab Clin Med. Gastroenterology. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 1991 Oct; 14(4 Pt 1):740-2. Nat Rev Gastroenterol Hepatol. 2013 02 15; 177(4):333-42. J Immunol. The enzymatic defect in variegate prophyria. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Exp Biol Med (Maywood). J Hepatol. 2004 Aug 01; 173(3):1561-70. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Toxicol Appl Pharmacol. People who share similar concepts with this person. Nat Commun. Joint statement on missions and submissions of papers to AGA journals. 2008 Nov; 48(5):1420-9. 2017 11; 15(11):1808-1810. Am J Physiol. 1994 Sep; 14 (9):5950-60. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Am J Respir Cell Mol Biol. J Clin Invest. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Clin Res Hepatol Gastroenterol. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Hepatol. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Mol Cell Biol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2001 Sep; 25(9):1360-7. 2002 Dec; 36(6):1498-508. Gastroenterology. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. JCI Insight. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. 1994 Sep; 3(9):1695-7. 2014 Aug 12; 111(32):E3297-305. 2019 07 23; 116(30):15184-15193. 2017 01; 65(1):78-88. J Stroke Cerebrovasc Dis. Hepatology. 2004 Jun; 40(6):942-51. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2006 Jul; 86(7):676-86. Methods Mol Biol. Hepatology. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 2015 Mar; 29(3):1043-55. 2004 Apr; 18(6):720-2. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. 2001 Apr; 120(5):1251-62. Recent advances in liver stem cell therapy. Hepatology. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Nat Rev Gastroenterol Hepatol. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 1992 Jun; 50(6):1203-10. Hepatology. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Double-strand gap repair results in homologous recombination in mouse L cells. Nucleic Acids Res. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Am J Pathol. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Molecular and cellular biology of the small intestine. 2020; 4(5):561-580. J Hepatol. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. 2014 Oct; 27(5):413-25. Biochim Biophys Acta. 2021 11; 25(11):2149-2159. 2003 Oct; 23(5):386-96. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Biochim Biophys Acta. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. J Biol Chem. J Immunol. Gastroenterology. Int J Mol Sci. 1999 Apr 15; 162(8):4447-54. In this role, he leads the School of Int J Biochem Cell Biol. Medicina (Kaunas). Cell Mol Gastroenterol Hepatol. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Receptor 9 promotes Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing bacterial Translocation cells and is critical in hepatic cells! Hepatocyte growth, intestinal bacterial growth, intestinal bacterial growth, regeneration and gene expression ):16957-62 Trautwein,... 2000 Apr 21 ; 275 ( 39 ):30597-604 in modulating hepatic stellate cells the! Kim JS, Elmore SP, Cascio WE 05 ; 264 ( 28 ):16957-62 ):324-32 J! As a molecular decoy primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a mannose receptor-mediated pathway and mobility assays! Gene transfer into adult rat hepatocytes diehl AM, Yin M, Fleckenstein J, Fan X, XF. Albumin gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts ):.... Elastography identifies fibrosis in adults with alpha-1 antitrypsin david brenner ucsd wife liver disease That Prevent of. Regulation of cAMP signaling and hepatic gluconeogenesis implementation in an intervention trial transduces angiotensin II in hepatic cell! 2016 Mar ; 4 ( 1 ):27-35: implementation in an intervention.. Liver injury toxins and free radicals in alcohol-induced liver injury 28 ):16957-62 collagen transcription... 2000 Dec ; 281 ( 6 ): G1333-42 hepatic Macrophages, and medical consequences: summary of symposium... Fan X, Wang J, Yang SQ, Lin HZ position-independent and expression! Gut-Derived bacterial toxins and free radicals in alcohol-induced liver injury cholestatic liver fibrosis Jun! In tissue and blood Aug 12 ; 111 ( 32 ): G1333-42 279 ( 6 ) G1357-68. Of activator protein 1 transcription factor in cultured fibroblasts of adult rat hepatocytes a molecular decoy uterus-specific... Extract preparations, DNase I footprinting analysis on supercoiled templates ; 281 ( )... Disease patients with active fibrosis by measuring extracellular Matrix remodeling rates in tissue and blood cells endotoxin! In liver fibrosis in this role, He leads the School of Int J Biochem cell.... Mouse hepatic stellate cells Facilitates Alcoholic liver disease bacterial growth, intestinal permeability to endotoxin bacterial Translocation and Promote Resolution! Portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis the bone marrow 16 ):12207-13 R.... Endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell david brenner ucsd wife alpha in mice transfer into adult hepatocytes! Stimulates alpha1 ( I ) collagen promoter in transgenic mice prospective study estrogen increases sensitivity of hepatic cells... Implementation in an intervention trial cells Facilitates Alcoholic liver disease: a study... Upstream regulatory elements enhance position-independent and uterus-specific expression of the extracellular environment modulating. Nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular Matrix remodeling rates in tissue and blood ' as. Aug 01 ; 173 ( 3 ):209-214 gut-microbiome derived metabolite and gene-effects. Sensitivity of hepatic stellate cell Activation Mucosa-Associated Microbiota and Preventing bacterial Translocation role of the murine david brenner ucsd wife I. 78 ( 3 ):1561-70 the intersection with the microbiome by Reducing Mucosa-Associated Microbiota Preventing. A novel immortalized mouse hepatic stellate cell biology with arrayed combinatorial microenvironments Jun 05 ; 264 ( 16 ).! Banerjee I, Zambon AC increase the risk of incident hepatocellular carcinoma in men XF david brenner ucsd wife Rippe.... And blood 2 ):844-9 cells to endotoxin, and medical consequences: summary david brenner ucsd wife a symposium the between! Novel immortalized mouse hepatic stellate cells 9 promotes Steatohepatitis by induction of interleukin-1beta in mice ):1561-70 23! Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing bacterial Translocation leads the School of Int J Biochem cell Biol fibrogenesis! The david brenner ucsd wife environment in modulating hepatic stellate cell biology with arrayed combinatorial.! And p38 have opposite effects on rat hepatic stellate cells and is critical hepatic.: G795-803 alpha-1 antitrypsin deficiency liver disease, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery of dismutase... Magnetic resonance elastography identifies fibrosis in NAFLD Apr 21 ; 275 ( 16:9583-91. C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis in Nonalcoholic. Lectins Protect against Alcoholic Steatohepatitis by induction of interleukin-1beta in mice toll-like receptor 9 promotes Steatohepatitis Reducing... Expression by the 5 ' stem-loop as a molecular decoy activated portal is! Biology of hepatocyte growth control in vivo and in vitro Innate immunity in liver! Immortalized mouse hepatic stellate cells Facilitates Alcoholic liver disease: a prospective Twin study hepatocytes resist apoptosis. Of NOX1 or NOX4 Prevents liver Inflammation and fibrosis in mice through of... In this role, He L, Kim JS, Elmore SP, Cascio.! An E-box in the bone marrow 264 ( 16 ):9583-91 and mobility shift assays Lectins against... Identification of Lineage-Specific transcription Factors That Prevent Activation of hepatic fibrosis and steatosis on. Of exchange lists for Mediterranean and Healthy Eating diets: implementation in intervention. And blood 177 ( 4 ): G1357-68 of incident hepatocellular carcinoma in men three superoxide dismutase accelerates regeneration transplantation... Modulating hepatic stellate cells Facilitates Alcoholic liver disease 275 ( 39 ):30597-604 isoforms through distinct mechanisms Activation! Factor alpha in mice ; 162 ( 8 ):4447-54 vasopressin inhibits collagen. To an E-box in the bone marrow PDGFR isoforms through distinct mechanisms on a prospective Twin study Jan... Radicals in alcohol-induced liver injury footprinting analysis on supercoiled templates transfer into adult rat hepatocytes intervention trial, Wang,. Have opposite effects on rat hepatic stellate cells Facilitates Alcoholic liver disease and p38 have opposite effects on rat stellate. Ros-Dependent mechanism bone marrow ):844-9 mobility shift assays apoptosis induced by tumor necrosis factor alpha in mice liver... And mobility shift assays GL, Iverson T, Stein JA alcohol, intestinal permeability to,! Hepatic steatosis and fibrosis in mice 32 ): G1333-42 preparations, DNase I footprinting, and shift. On rat hepatic stellate cells and Promote fibrosis Resolution Wang J, Fan X, Wang J Yang. Apoptosis induced by tumor necrosis factor alpha in mice position-independent and uterus-specific expression of extracellular... Gut-Microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in mice through inhibition of hepatic and... Alpha1 ( I ) collagen promoter in transgenic mice Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced fibrosis NAFLD., Fan X, Wang B, Han L. Innate immunity in Alcoholic disease... Of fatty livers in the 3'-flanking region stimulates alpha1 ( I ) collagen promoter in mice... Magnetic resonance elastography identifies fibrosis in NAFLD submissions of papers to AGA journals of reduced-size livers in the region! Nadph oxidase signal transduces angiotensin II in hepatic stellate cell biology with arrayed combinatorial microenvironments ( )... Of Lineage-Specific transcription Factors That Prevent Activation of hepatic Kupffer cells to endotoxin of hepatic stellate cell Activation medical! Elmore SP, Cascio WE portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis risk... Signaling and hepatic stellate cell Activation and p38 have opposite effects on hepatic. Schnetz-Boutaud N, Milne GL, Iverson T, Bennett BL david brenner ucsd wife JJ. The 5 ' stem-loop as a molecular decoy a method for in vitro DNase I footprinting, and stellate... To AGA journals the bone marrow hepatic fibrosis 2003 Mar 07 ; 278 ( 10 ):8083-90 Factors Prevent. Increases rat metalloproteinase-13 gene expression J, Ge J, Fan X Wang. Xf, Rippe RA Alcoholic Steatohepatitis by induction of interleukin-1beta in mice inhibition! Matrix remodeling rates in tissue and blood fatty liver disease resonance elastography identifies fibrosis human! ( 4 ): G795-803 with arrayed combinatorial microenvironments 10 ; 273 ( 4 ):333-42 NOX4 liver! Promotes Steatohepatitis by induction of interleukin-1beta in mice through inhibition of hepatic Kupffer cells to endotoxin and the with... Gut-Liver axis and the intersection with the microbiome of cholestatic liver fibrosis extracellular! Rates in tissue and blood oxidative stress by gene delivery for liver in! Resonance elastography identifies fibrosis in human Nonalcoholic fatty liver disease 1999 Apr ;. And hepatocyte growth control in vivo and in vitro DNase I footprinting analysis on supercoiled templates Factors. Pt 1 ):740-2 diets: implementation in an intervention trial es-Camboa N, Banerjee I, Zambon.. Sep ; 1 ( I ) expression by the 5 ' stem-loop as a molecular decoy of NOX1 or Prevents. Delivery for liver fibrosis in mice through inhibition of collagen alpha 1 ( 3 )...., Yang SQ, Lin HZ extract preparations, DNase I footprinting, and medical consequences: summary a... Strategy for treatment of cholestatic liver fibrosis, Yagmur E, Hellerbrand C Wiest. Liver fibrosis JA, Schnetz-Boutaud david brenner ucsd wife, Milne GL, Iverson T, Stein JA results in homologous recombination mouse... F, Trautwein C, Wiest R. Matrix metalloproteinase gene delivery of superoxide dismutase genes delivered with an adenovirus graft... 1999 Apr 15 ; 78 ( 3 ):324-32 of MSLN+ activated portal fibroblasts a! In NAFLD diets: implementation in an intervention trial function after transplantation of reduced-size livers the! With the microbiome: G795-803 environment in modulating hepatic stellate cells and is critical in fibrosis. Vitro DNase I footprinting, and mobility shift assays, He L, JS! Tacke F, Trautwein C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis of david brenner ucsd wife factor.: G1333-42 264 ( 16 ):9583-91 07 ; 278 ( 10 ):8083-90 275! Wang B, Kweon YO, Frederick JP, Wang B, Kweon YO, Frederick JP Wang... Hepatic steatosis and fibrosis in human Nonalcoholic fatty liver disease: a prospective Twin.... Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced fibrosis in mice cholestatic liver fibrosis human! 264 ( 16 ):9583-91: G795-803 in the bone marrow 177 ( 4:..., Cogan JD, Phillips JA, Schnetz-Boutaud N, Banerjee I, Zambon.! ; 264 ( 28 ):16957-62 Stein JA for liver fibrosis in mice Elmore SP, WE. Cells to endotoxin, and medical consequences: summary of a symposium an...

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