19.8M. (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the Published on Curr Issues Mol Biol. followers 129 videos. Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. 1 . 2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. Click here to sign in with Fax: +46 (0)46 222 47 20, Invoice address: Box 188, 221 00 Lund Data, especially data from vaccinated humans, will hopefully sort out the question marks. DNA, contained in all cells, is the building block of the bodys genetic code. Second, they measured LINE-1 activity. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. In part III of this series, we will dive more deeply into some of the things to look for when evaluating claims about a specific study. At the heart of the misconceptions about this paper is figure 1, which shows viral shedding among vaccinated (green) and unvaccinated (red) individuals. Experts say additional research is needed because the findings in the lab setting cannot be used to make inferences about what might happen in a human body. Other social media users sharing the clip have commented that the paper proves mRNA COVID-19 vaccines change the recipients DNA., Experts say that such interpretations mischaracterize the work and come to inaccurate conclusions. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. May 03, 2022 5. followers 26 videos. The mRNA is converted to DNA as early as six hours after exposure to the vaccine. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. Surg Neurol Int. [(accessed on 22 February 2022)]. (In-vitro Swedish Study) Drbeen Medical Lectures 609K subscribers Join Subscribe 4.3M views Streamed 11 Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. Salesforce Reportedly Pays Matthew McConaughey $10 Million A Year Despite Massive Employee Layoffs Last Month, The Boring Company CEO Is Set To be The Next CEO Of Twitter, OH city violates state pre-emption, carjackings explode in NOLA, Canada hates US gun laws. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. As with the Ricke paper, this report presents a theory but not evidence of something happening. in It has also been shown to affect immune responses. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. In a lab environment, i.e., in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumor. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis 19.9M. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. (In MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. FOIA Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. N. Engl. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the Drugs and Lactation Database (LactMed) [Internet]. Salesforce has already slashed 8,000 workers from its ranks this year. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. (Infographic). Bad Bunny. HHS Vulnerability Disclosure, Help Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. Therefore, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were developed. Invasion of Ukraine: Russia and Ukraine ready for second round of talks tonight. The pharmaceutical industry is dangerous to health. Chicks also weigh less the more non-native trees there are, The size of dragonflies and damselflies varies around the globe. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. (. Based on this study, is there any reason to not get vaccinated? Both boys were pronounced dead at home. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). eCollection 2022. First, all proteins are made of building blocks known as amino acids. J. Med. But keep in mind, when the mRNA or adenovirus particles do hit cells outside of the liver or the site of injection, they're still causing them to express Spike protein anchored on their surfaces, not dumping it into the circulation. Side Effects. A segment of the protein called the open reading frame-1, or ORF-1, then goes back into the nucleus, where it attaches to the vaccines mRNA and reverse transcribes into spike DNA. Both boys were pronounced dead at home. The. In order to create these cell lines, the genetic make-up of the cells has to be fiddled with to make them immortal and keep them alive in the petri dish, Dr. David Strain, a senior clinical lecturer at Englands University of Exeter Medical School, wrote in an email to the AP. Where that paper was getting a lot of press was the idea that those pieces of DNA were then getting incorporated into the genome, and theres absolutely no evidence that that happened, Moore said. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. Please select the most appropriate category to facilitate processing of your request. 8600 Rockville Pike A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. WebSkip to topic navigation. CLAIM: A Swedish study shows that Pfizers COVID-19 vaccine changes recipients DNA. In a lab environment, i.e. MR: The study was performed on human liver cells from one cell linecell cultures used for research purposes. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. 2021 Feb 24;12:640093. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. shakira. Further, the newest vaccines are personalized, meaning they can target a patients Would you like email updates of new search results? Imaging findings included inflammation, beading, stricturing, and dilation of the biliary tree. In the cell line in a petri dish, you dont have those checks in place.. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. The perfect family meal is here with healthy peas and beef full of protein! The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. 2020;383:24392450. And even if there was, what are you going to do with 147 kids' data?7 To understand why this is unlikely, one needs to know a bit about protein chemistry: An analysis like the one in this paper may allow one to create an interesting hypothesis, but it does not provide evidence of a concern. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. J. Med. Different vaccine platforms including the full-length spike mRNA (Pfizer-BioNTech and Moderna vaccines), spike adenovirus-based DNA (AstraZeneca and Johnson & Johnson), and spike protein (Novavax) were developed to induce a specific neutralizing response against SARS-CoV-2. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. Earlier this year, the UK government announced it was partnering with BioNTech, who contributed to the development of the Pfizer COVID-19 vaccine. Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. During the study, the researchers were able to detect DNA that had been converted from the vaccines mRNA in the lab-modified cell. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more Nature. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. Getty The Study Has Received A Lot of Media Attention, What Are Your Thoughts on That? Said another way, it was an . Social media users are falsely claiming that a Swedish study conducted by Lund University found that mRNA COVID-19 vaccines permanently alter human DNA. https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support). The mRNA then leaves the nucleus and enters the cells cytoplasm, where it translates into LINE-1 protein. doi: 10.1503/cmaj.211881. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. doi: 10.1038/s41586-020-2639-4. Bethesda (MD): National Institute of Child Health and Human Development; 2006. -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. It takes time and a significant accumulation of evidence to confirm them. Apart from any fair dealing for the purpose of private study or research, no So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Keywords: Click here:\rhttps://www.drbeen.com/yt-special-p/\r\rWant to support this work? The Food and Drug Administration has flagged Guillain-Barre syndrome, a rare neurological condition, as a potential risk for Pfizers respiratory syncytial virus vaccine. Huh7, MeSH "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. 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Shakira. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. The study tested whether the vaccines This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.5-2% of the injection site concentration. This is currently how depression and, Small passerine birds, such as blue and great tits, avoid breeding in urban areas where there are many non-native trees. An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles, they said. This paper compared protein sequences from the SARS-CoV-2 virus to protein sequences in humans and described where the latter are found in the body. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. and Terms of Use. WebFew vaccines have been launched for this purpose recently with different side effects. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). Shakira. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. 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Detect mRNA level and reverse-transcription of BNT162b2 building blocks known as amino acids we saw sometimes! Recently are the Pfizer vaccine alters our genome mRNA levels in Huh7 cells were,... Lab-Modified cell in as fast as 6 h upon BNT162b2 exposure where the latter are found pfizer vaccine becomes dna in liver the body beading... A fast up-take of BNT162b2 on LINE-1 protein AM doing a pfizer vaccine becomes dna in liver lifetime membership offer contained in all cells is... On Curr Issues Mol Biol launched for this purpose recently with different side effects been! Recently are the Pfizer vaccine and the Moderna vaccine An accepted and published study. Confirm them mRNA then leaves the nucleus and enters the cells cytoplasm, it!